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Multivariate analysis of prognostic factors in the non‐Hodgkin's malignant lymphomas
Author(s) -
Bloomfield Clara D.,
Goldman Anne,
Dick Fred,
Brunning Richard D.,
Kennedy B. J.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<870::aid-cncr2820330337>3.0.co;2-6
Subject(s) - medicine , lymphoma , bone marrow , stage (stratigraphy) , multivariate analysis , oncology , pathology , survival analysis , prognostic variable , b symptoms , cancer , disease , paleontology , biology
The factors important in predicting survival in the non‐Hodgkin's malignant lymphomas have not previously been clearly identified. This study evaluates the prognostic usefulness, in predicting survival, of a modified Rappaport pathologic classification, the Ann Arbor clinical staging classification, initial bone marrow involvement, symptoms, extranodal involvement, age, and sex in 128 consecutive adult patients with malignant lymphoma. Conventional life table analysis indicates that symptoms, pathology, and clinical stage are the most important factors in predicting survival. However, multiple regression analysis identifies pathology, symptoms, and bone marrow involvement as the three most important variables. Clinical stage when considered with other risk factors (in the multiple regression analysis) adds little prognostic information. Age, sex, and extranodal involvement do not significantly influence survival in either analysis. Pathology, symptoms, and bone marrow involvement appear most important in designing adequate clinical treatment trials in patients with non‐Hodgkin's lymphoma.