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Lipid‐rich carcinoma of the breast. A clinicopathologic analysis of 13 examples
Author(s) -
Ramos Carlos V.,
Taylor Herbert B.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<812::aid-cncr2820330328>3.0.co;2-4
Subject(s) - medicine , pathology , carcinoma , lobular carcinoma , metastatic carcinoma , breast carcinoma , mammary carcinoma , lymph , mammary gland , cancer , breast cancer , ductal carcinoma
A critical review of over 900 mammary carcinomas treated at St. Louis University Hospitals disclosed 13 that fulfilled the histologic picture of lipid‐rich carcinoma. All clinical and pathologic data were tabulated; 1 case was studied by electron microscopy. Five of the patients were dead within 2 years, and 2 others had evidence of metastatic tumor within 2 years. One patient died 6 years after treatment. On the basis of the following characteristics we believe lipid‐rich carcinomas should be regarded as a specific type of mammary carcinoma: 1. The presence of non‐degenerative lipid material within the cytoplasm of tumor cells; 2. The presence of intramitochondrial crystals; 3. The pattern of metastatic involvement of lymph nodes and the orbit; 4. The presence of intraductal and lobular carcinoma in situ associated with this type of tumor; and 5. The more aggressive clinical behavior.