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Down's syndrome: Establishment of lymphoblastoid cell lines with trisomy 21
Author(s) -
Miyoshi Isao,
Yoshimoto Shuko,
Fujiwara Sunao,
Hiraki Kiyoshi,
Kimura Shunsuke
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<739::aid-cncr2820330320>3.0.co;2-8
Subject(s) - trisomy , down syndrome , lymphoblast , cell culture , peripheral blood , chromosome , virology , medicine , epstein–barr virus , virus , antibody , aneuploidy , capsid , karyotype , microbiology and biotechnology , immunology , biology , genetics , gene
Three continuously growing lymphoblastoid cell lines were established from peripheral blood of 3 of 16 patients with Down's syndrome (DS). All these cultures revealed the presence of chromosome constitution of trisomy 21 and Epstein‐Barr virus (EBV) particles. Although EBV capsid antibody levels were generally higher in DS, the frequency of and period to cell line establishment were similar between DS patients and normal individuals.