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Nonsecretory myeloma. Immunofluorescent demonstration of paraprotein within bone marrow plasma cells
Author(s) -
Arend William P.,
Adamson John W.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<721::aid-cncr2820330317>3.0.co;2-d
Subject(s) - bence jones protein , pathology , plasma cell , bone marrow , hypogammaglobulinemia , medicine , plasma cell myeloma , multiple myeloma , staining , antibody , cytoplasm , immunoglobulin light chain , immunology , biology , microbiology and biotechnology
A patient with multiple myeloma is reported with hypogammaglobulinemia and the absence of a paraprotein in the serum, and absence of Bence Jones protein in the urine. The clinical course was malignant with massive plasma cell infiltration of the liver and kidneys contributing to insufficiency of each organ. Immunofluorescent studies on bone marrow smears demonstrated bright staining for kappa and weak staining for gamma antigenic determinants within the cytoplasm of the plasma cells. It is suggested that the aberrant intracellular proteins were unable to be combined into a full immunoglobulin molecule or that a defect was present in the secretory pathway.