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Studies concerning the regional lymph node in cancer. IV. Tumor inhibition by regional lymph node cells
Author(s) -
Fisher Bernard,
Saffer Elizabeth,
Fisher Edwin R.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<631::aid-cncr2820330307>3.0.co;2-g
Subject(s) - lymph node , lymph , spleen , lymphatic system , medicine , in vivo , tumor cells , cancer research , lymph node stromal cell , in vitro , pathology , primary tumor , cytotoxicity , cancer , immunology , biology , metastasis , biochemistry , microbiology and biotechnology
Observations in two different syngeneic tumor‐host systems utilizing in vivo neutralization and in vitro cytotoxicity have revealed that even after tumors had been present for a prolonged period of time, regional lymph node cells were capable of interfering with the growth of tumor cells. Neither distant LNCs nor spleen cells ever fully displayed that characteristic. Only when animals approached death from their tumors did RLNCs demonstrate loss of their neutralizing capability. Inhibition of growth of tumor cells by RLNCs was not impaired for at least as long as 2 months following removal of primary tumors. Cells obtained at that time from other sources failed to display such a capability. The findings are compatible with others from this laboratory which have indicated that RLNs are unique from the rest of the lymphoreticular system insofar as the immunologic response of a host to its tumor is concerned. They also suggest that disseminated living tumor cells gaining access to RLNs may be destroyed in those structures, and that the finding of negative lymph nodes may be the result of such a circumstance rather than that a tumor had been removed prior to its lymphatic dissemination.