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Plasma cell leukemia: Detailed studies and response to therapy
Author(s) -
Shaw Michael T.,
Twele Thomas W.,
Nordquist Robert E.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197403)33:3<619::aid-cncr2820330305>3.0.co;2-0
Subject(s) - vincristine , medicine , prednisone , cyclophosphamide , melphalan , plasma cell leukemia , leukemia , plasma cell , chemotherapy , pathology , cancer research , bone marrow
A case of plasma cell leukemia (PCL) was shown by immunoelectrophoretic and immunofluorescent studies to be producing kappa light chains. Cyto‐chemical staining of the cells revealed strong β‐glucuronidase, oil red 0, and acid phosphatase positivity. Electron microscopy demonstrated various stages in plasma cell development. A good partial remission was obtained following a combination regimen of cyclophosphamide, vincristine, cytosine arabinoside, and prednisone (COAP). Intermittent high dosage melphalan and prednisone were used at a later stage. PCL may have an improved prognosis using aggressive combination chemotherapy.