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Immunologic similarities between fetal cell antigens and tumor cell antigens in guinea pigs
Author(s) -
Grant John P.,
Ladisch Stephan,
Wells Samuel A.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197402)33:2<376::aid-cncr2820330212>3.0.co;2-r
Subject(s) - antigen , fetus , guinea pig , medicine , transplantation , immune system , pathology , immunology , biology , andrology , pregnancy , genetics
Inbred Strain 2/N guinea pigs were immunized with irradiated cells from two different methylcholanthrene‐induced syngeneic guinea pig sarcomas (MCA‐A and MCA‐25), syngeneic second trimester fetal tissue, or allogeneic Strain 13/N guinea pig tissue. In one experiment immunized animals and multiparous Strain 2/N females were injected intradermally with membrane antigen extracts (MEA) of each immunizing tissue and normal Strain 2/N tissue, and evaluated for development of delayed cutaneous hypersensitivity reactions (DCHR). Animals immunized to either tumor showed positive DCHR to MAE of that tumor and occasional reactions to MAE of the other tumor. Multiparous females, and females immune to second trimester fetal tissue, developed positive DCHR to fetal tissue MAE and to MAE of each tumor. In a second experiment, immunized animals and multiparous females were challenged subcutaneously with viable MCA‐25 tumor cells. Significant resistance to tumor growth was demonstrated in animals immunized to either tumor, multiparous females, and animals immunized to second trimester fetal tissues. A similarity between fetal antigens and tumor‐associated transplantation antigens of two MCA‐induced guinea pig sarcomas is suggested.