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Familial arrhenoblastoma and thyroid adenoma
Author(s) -
Jensen Robert D.,
Norris Henry J.,
Fraumeni Joseph F.
Publication year - 1974
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197401)33:1<218::aid-cncr2820330132>3.0.co;2-z
Subject(s) - medicine , thyroid , thyroid adenoma , neoplasm , adenoma , thyroid tumors , thyroid neoplasm , pathology , pediatrics , thyroid cancer , endocrinology , thyroid carcinoma
A family is presented in which a mother and her two daughters had ovarian tumors during childhood. Arrhenoblastoma was present in both daughters, the sixth reported familial occurrence of this rare neoplasm. Thyroid adenomas also developed in several members of this family. A relationship between the tumors is strengthened by the high frequency of thyroid growths found in a separate survey of arrhenoblastoma in young women. It seems likely that this tumor complex is genetically determined, and distinct from the familial neoplastic syndromes already described.