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Lymphosarcoma and reticulum cell sarcoma in children. A retrospective study of 172 cases
Author(s) -
Lemerle Mlchèle,
GerardMarchant Rémi,
Sarrazin Daniéle,
Sancho Héléne,
Tchernia Gll,
Flamant Françoise,
Lemerle Jean,
Schweisguth Odile
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1499::aid-cncr2820320629>3.0.co;2-d
Subject(s) - medicine , stage (stratigraphy) , lymphatic system , reticulum cell sarcoma , survival rate , retrospective cohort study , sarcoma , disease , survival analysis , surgery , pathology , paleontology , biology
The clinical features and survival rates of 112 cases of lymphosarcoma and 60 cases of reticulum cell sarcoma in children under 15 years of age, treated between 1950 and 1971, form the basis of this report. Some modifications of the Ann Arbor Classification are discussed, taking into account the local and distant dissemination of the disease and the importance of tumors arising outside the lymphatic organs. Forty of 91 Stage I and II patients, 5 of 44 Stage IVC patients, and 2 of 36 Stage IVD patients are living with a minimum followup period of 9 months. The over‐all survival rate is 27%. All deaths occurred before the 30th month following diagnosis, the survival curve not changing thereafter. A statistical analysis has been made. Age, sex, and his‐tologic type have not been found prognostically significant in this series. The initial stage has an independant significant prognostic value: The survival rate is 58% for the 54 Stage I patients, 24% for the 36 Stage II patients, and 8% for the 79 Stage IV patients. The 24 patients with non‐lymphatic forms have a 69% survival rate, as compared to 36% for the 67 patients with lymphatic forms.