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Hepatocellular carcinoma presenting with pathologic fracture due to bone metastases
Author(s) -
Talerman A.,
Magyar E.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1477::aid-cncr2820320626>3.0.co;2-u
Subject(s) - medicine , hepatocellular carcinoma , pathology , autopsy , metastatic carcinoma , differential diagnosis , carcinoma , biopsy
Two cases of hepatocellular carcinoma presenting with pathologic fracture due to bone metastases are reported. The patients did not exhibit clinical evidence of liver disease on presentation, and there was no previous history of liver disease. Liver function tests were normal in 1 case, while in the other the only abnormality was a slightly raised alkaline phosphatase. In 1 case the diagnosis was made by needle biopsy of a metastatic bone lesion, and in the other only at autopsy. The literature concerning this mode of presentation of hepatocellular carcinoma, and of liver cell carcinoma with skeletal metastases is reviewed. It is considered that hepatocellular carcinoma should be included in the differential diagnosis of carcinoma metastatic to bone.