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Light and electron microscopic observations on a congenital insulinoma
Author(s) -
Rawlinson Donald G.,
Christiansen Robert O.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1470::aid-cncr2820320625>3.0.co;2-h
Subject(s) - insulinoma , medicine , hypoglycemia , autopsy , pathology , pancreas , electron microscope , adenoma , insulin , physics , optics
An insulinoma was found at the autopsy of a 48‐day‐old infant. The infant presented with documented hypoglycemia at 8 hours of age and the hypoglycemia continued throughout life despite medical therapy. The insulinoma was grossly a distinct nodule. Histologically, it was well‐defined and characteristic of an islet cell adenoma. The tumor cells contained granules that were positively stained with aldehyde fuchsin. With the electron microscope a heterogeneous granule cell population similar to those in the beta‐cell adenoma of the adult was seen.