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A comparative analysis of chromosomes and diagnostic cytology in effusions from 58 cancer patients
Author(s) -
Miles Charles P.,
Wolinska Wanda
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1458::aid-cncr2820320624>3.0.co;2-z
Subject(s) - medicine , chromosome analysis , chromosome , cytology , cancer , abnormality , chromosome abnormality , effusion , pathology , karyotype , surgery , genetics , biology , gene , psychiatry
A study has been done of the possible use of chromosome analysis in the diagnosis of cells in effusion. Analyzable preparations were made from 63 samples (from 58 patients). If gross chromosome abnormality indicates cancer, then 24 of these cases could be so diagnosed. With conventional screening 38 cases were diagnosed as positive. Thus chromosome analysis cannot substitute for the conventional approach. Two cases, negative by conventional diagnosis, were positive by chromosome analysis. This represents approximately a 4% improvement in accuracy. Most of these patients had been treated by x‐ray and/or chemotherapy, thus complicating the interpretation of chromosome abnormalities. Chromosome analysis might be more helpful in populations with fewer treated patients.