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Changing pattern of some pathologic parameters of mammary carcinoma
Author(s) -
Fisher Edwin R.,
Taylor Muriel
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1380::aid-cncr2820320616>3.0.co;2-h
Subject(s) - mammary carcinoma , medicine , incidence (geometry) , carcinoma , pathology , mammary gland , cancer , breast cancer , physics , optics
Review of the histologic type, histologic and nuclear grades, and degree of local cell reaction in 606 mammary carcinomas encompassing the period of 1955–1972 inclusively was performed. Observations disclosed a significant trend for an increasing incidence of infiltrating ductal carcinomas without special features (NOS), and tumors of higher (less favorable) histologic grade with time. A suggestively significant decrease in severe cell reactions to the tumors was also noted. These findings are paradoxical to evidence which suggests an increasing incidence and stable or increasing survival rates for mammary carcinoma, since they have been related to a less favorable prognosis. Reasons for such change in these histopathologic features are unclear, but do not appear to be age‐related. Nevertheless, such information would appear pertinent to epidemiologic considerations relating to mammary carcinoma.