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Familial gastric cancer and immunologic abnormalities
Author(s) -
Creagan Edward T.,
Fraumeni Joseph F.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197312)32:6<1325::aid-cncr2820320606>3.0.co;2-9
Subject(s) - stomach , cancer , medicine , stomach cancer , immunodeficiency , immune system , immunology , autoimmunity , antibody , genetic predisposition , pathology , disease
Stomach cancer developed in 12 members of an inbred kindred over 4 generations. The family resided in a rural county where the reported mortality from this cancer has been significantly higher than in the surrounding region, but no specific environmental influence could be identified. A battery of laboratory studies applied to 16 family members, including 1 recently diagnosed with stomach cancer, revealed a high frequency of cases with antibody to gastric parietal cells and cell‐mediated immune defects. These observations suggest that mechanisms of autoimmunity and immunodeficiency, consistent with a genetic defect of T‐lymphocytes, are involved in this family's susceptibility to stomach cancer.