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Surgery of bladder and prostatic neoplasms in children
Author(s) -
Clatworthy H. William,
Braren Victor,
Smith John P.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197311)32:5<1157::aid-cncr2820320524>3.0.co;2-h
Subject(s) - medicine , rhabdomyosarcoma , prostate , surgery , vincristine , embryonal rhabdomyosarcoma , radical surgery , chemotherapy , sarcoma , cancer , pathology , cyclophosphamide
Rhabdomyosarcoma is the common malignant soft tissue tumor of childhood. Twelve of 67 cases recently reviewed from this institution arose in the bladder or prostate (6 are surviving). Until recently and regardless of the primary site, the reports of successful treatment of this aggressive embryonal neoplasm have been limited to very small series or to isolated cases managed by radical mutilative surgery. Now, combined therapy, as has proven so effective in Wilms' tumor, and utilizing “reasonable surgery” (excision of all gross tumor), tolerable x‐ray therapy (Cobalt 60 2‐4000 R according to age in 3–4 weeks), and repeated courses of Actinomycin D and Vincristine (9‐week cycles for at least a year), is recommended. At Ohio State University the curability rate in all types of rhabdomyosarcoma including all bladder and prostatic lesions has improved spectacularly from 14% prior to 1967 to 71% (corrected survival by life table method) in the last 38 cases treated.