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The surgical treatment of nephroblastoma (Wilms' tumor)
Author(s) -
Ehrlich Richard M.,
Goodwin Willard E.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197311)32:5<1145::aid-cncr2820320521>3.0.co;2-x
Subject(s) - medicine , wilms' tumor , radiation therapy , nephrectomy , surgery , chemotherapy , transplantation , surgical excision , disease , lymphadenectomy , cancer , kidney
Utilizing the combined therapeutic modalities of surgery, radiotherapy, and chemotherapy, the treatment of Wilms' tumor has improved to provide an overall survival rate of 80%. Surgical excision, however, remains the cornerstone of therapy. Radical nephrectomy, whenever possible, is utilized for unilateral tumors and a thorough lymphadenectomy is advocated. Surgical excision of isolated pulmonary metastases should also be performed. An aggressive approach to bilateral Wilms' tumor is suggested. The potential of renal transplantation in bilateral disease has not yet been fully realized, and at the present time transplantation should only be offered to those patients whose disease is not controllable with the usual modalities of surgery, radiotherapy, and chemotherapy.