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Hodgkin's disease—A report from Buenos Aires, Argentina
Author(s) -
Braylan Raul,
Pascuccelli Hector,
Stadecker Miguel,
Morgenfeld Marcos C.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197310)32:4<879::aid-cncr2820320419>3.0.co;2-d
Subject(s) - nodular sclerosis , medicine , pathology , disease , multiple sclerosis , lymph , immunology , lymphoma , hodgkin lymphoma
The Rye classification was applied to 144 cases of Hodgkin's disease in Buenos Aires, Argentina. The distribution of the histologic types was determined and correlated with the sex, age, and survival of the patients. The most common histologic types were mixed cellularity and nodular sclerosis. In agreement with observations by others, the nodular sclerosis type affected predominantly young females and carried a significantly better prognosis than the mixed cellularity type. The frequency of the histologic groups was compared with other series from various regions of the world. Similarities and discrepancies were found, the latter due to differences in patient populations, in histologic interpretation, or true geographical variations. To test the reproducibility of the Rye classification, two pathologists undertook a blind study, and independently reached an overall agreement in 84% of the cases. Certain morphological features not sufficiently emphasized in the past were frequent in the nodular sclerosis type: the presence of numerous plasma cells, abundance of neutrophils, and deposits of iron pigment. The significance of these findings is not clear. The predominantly affected paracortical (thymus related) areas in partially involved lymph nodes may account for the impaired cellular immunity observed initially in patients with Hodgkin's disease.