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Radionuclide studies on the growth of intrahepatic tumors and of the infiltrated liver
Author(s) -
Spencer Richard P.,
Witek Joseph T.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197310)32:4<838::aid-cncr2820320414>3.0.co;2-z
Subject(s) - medicine , radionuclide , radionuclide therapy , lymphatic system , nuclear medicine , stomach , pathology , gastroenterology , physics , quantum mechanics
The suggestion is made that radionuclide scans of the liver can be used to measure the rate of growth of intrahepatic neoplasms. Techniques for accomplishing this are discussed, and the linear growth rate (change in diameter/time) is calculated. In 5 cases of metastatic tumors to the liver, the linear growth rate determined by use of the scans is in the range of 100 × 10‐ 3 to 400 × 10‐ 3 mm/day (periods of observation of from 43 to 694 days). In order to compare single intrahepatic tumors with those which infiltrate the liver, the need for estimates of tumor and hepatic weights is pointed out. In 2 cases of diffuse hepatic involvement (carcinoma of stomach, acute lymphatic leukemia) the estimated change in hepatic weight/day is 1.6 and 30.5 grams. Possible uses of the techniques are noted. These include showing the time course of hepatic involvement, comparing the growth of hepatic and pulmonary lesions before and after therapy, and comparing the observed rates with various growth hypotheses.