Premium
Electron microscope observation of viruslike particles in comedocarcinoma of the human breast
Author(s) -
Seman Gabriel,
Dmochowski Leon
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197310)32:4<822::aid-cncr2820320412>3.0.co;2-n
Subject(s) - endoplasmic reticulum , electron microscope , nucleoid , virus , virology , pathology , virus like particle , biology , biophysics , chemistry , medicine , microbiology and biotechnology , optics , physics , recombinant dna , biochemistry , escherichia coli , gene
We have previously reported the observation of viruslike particles resembling mouse mammary tumor and mouse leukemia virus particles in a number of breast tumor biopsy specimens. Viruslike particles of two different types have been observed by electron microscope examination of a breast tumor specimen of a patient with comedocarcinoma and Hashimoto's disease. The particles have all been found in endoplasmic cisternae of epithelial tumor cells. Viruslike particles of one type, represented by 80 millimicrons in size particles arranged in chainlike formations, showed some general features of the hamster type H virus particles; however, no distinct spokes originating from the nucleoid could be seen as described in type H particles. Viruslike particles of the other type resembled type C virus particles, but were larger (200 millimicrons) in size and, unlike type C particles, were found only in the cisternae of the endoplasmic reticulum. No viruslike particles have been found in biopsy specimens of two other patients with comedocarcinoma. The morphological characteristics of these viruslike particles are discussed in view of recent findings by others of virus particles in tissue cultures derived from breast and other types of human tumors.