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67 GA scintigraphy in acute leukemia
Author(s) -
Milder Michael S.,
Glick John H.,
Henderson Edward S.,
Johnston Gerald S.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197310)32:4<803::aid-cncr2820320410>3.0.co;2-s
Subject(s) - medicine , occult , scintigraphy , bone marrow , leukemia , bone scintigraphy , infiltration (hvac) , chemotherapy , osteomyelitis , radiology , acute leukemia , abscess , pathology , surgery , physics , alternative medicine , thermodynamics
In order to study the use of 67 Ga scintigraphy in systemic malignancies, 43 whole body rectilinear scans were performed on 30 patients with acute leukemia. Results of scintigraphy were correlated with bone marrow status and evidence of infection and leukemic masses. The indications for scanning included search for occult infections, documentation of abscesses and tumor infiltrate and evaluation of bone pain. Abnormally high 67 Ga activity was found in sites of leukemic involvement in untreated patients and those receiving chemotherapy. Over 80% of the patients with extensive leukemic marrow infiltration had increased bone activity, but only 27% of patients in remission had this pattern. Myeloblastomas were correctly identified in the breast, testes, and nasopharynx. Activity in these lesions also decreased after remission induction. Four patients with proven abscesses and osteomyelitis had strongly positive foci on 67 Ga scans. Abscesses decreased in activity after appropriate antibiotics. Abscesses were visualized in patients with white cell counts as low as 200 per cu. mm.