Premium
Therapy of mycosis fungoides with bleomycin
Author(s) -
Spigel Stuart C.,
Coltman Charles A.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197310)32:4<767::aid-cncr2820320406>3.0.co;2-x
Subject(s) - medicine , mycosis fungoides , bleomycin , prednisone , cyclophosphamide , vincristine , nitrogen mustard , dermatology , radiation therapy , chemotherapy , surgery , refractory (planetary science) , lymphoma , physics , astrobiology
A case of mycosis fungoides with universal plaque‐like, dermal infiltration and severe generalized exfoliation is described. This patient had been treated with topical nitrogen mustard, occlusive steroid dressings, total body electron beam therapy, total body orthovoltage superficial radiotherapy, and intensive combination chemotherapy (cyclophosphamide, vincristine, prednisone) during the 6‐year course of his disease, and had become refractory to all modalities. Bleomycin, a new antitumor antibiotic, was administered parenterally at a dose of 10 mg/m 2 twice weekly. Over a period of 12 weeks a complete response was achieved and has been maintained 8+ months with a low dose weekly bleomycin and burst cyclophosphamide and prednisone therapy. Toxicity has been minimal. The postulated mechanism for the success of this drug in therapy of this disease entity is discussed.