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Aspermia following lower truncal irradiation in Hodgkin's disease
Author(s) -
Speiser Burton,
Rubin Philip,
Casarett George
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197309)32:3<692::aid-cncr2820320323>3.0.co;2-i
Subject(s) - medicine , irradiation , nuclear medicine , radiation therapy , dosimetry , in vivo , surgery , biology , physics , microbiology and biotechnology , nuclear physics
Very little is known concerning the radiation affects on the spermatogenic epithelium of the human. This was studied by serial semen analysis in male patients with Hodgkin's disease. Dosimetry in vivo indicated that with an average daily dose of 12.0 rads, the testes receive a total dose of 140 to 300 rads during the inverted Y‐inguinal field treatment. Of 10 consecutive patients entered into the study, all were documented as being aspermic in the immediate post‐irradiation period. Comparison is made with those cases of accidental single dose irradiation of the testes reported in the literature. The fractionated irradiation caused aspermia for longer periods and more consistently than similar or larger single doses. This is new human evidence which supports the observation in animals that a particular mode of fractionated irradiation may be both more effective and efficient than single dose irradiation in producing the above specified endpoints.