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Comparison of fractionated versus split‐course irradiation on renal blood flow in mice
Author(s) -
Brown R. C.,
Glatstein Eli
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197309)32:3<524::aid-cncr2820320302>3.0.co;2-r
Subject(s) - medicine , kidney , fractionation , extraction ratio , urology , nuclear medicine , dose fractionation , parenchyma , radiation therapy , extraction (chemistry) , pathology , chromatography , chemistry
In clinical radiotherapy, the kidney is the organ within the upper abdomen most likely to limit the radiation dose. Since the parenchyma is a slow renewal system in terms of proliferation, the vascular network of the kidney has been suggested as the limiting factor. To investigate this possibility, we employed 86 Rb extraction by the kidney of C 3 H mice following intravenous injection as a measure of blood flow to the kidney. The kidneys of C 3 H mice were regionally irradiated according to the following fractionation schemes: single doses, three fractions per week for 3 weeks, and a split‐course of five fractions in 4 days, followed by a 10‐day gap and a repeat of five fractions in 4 days. The two dose levels for each fractionation schedule were calculated to be equivalent to 1000 rets and 2000 rets. Accordingly, the single doses were 1000 rads and 2000 rads. At 4 months, renal 86 Rb extraction was measured at the time of sacrifice of the animals. The data demonstrated that the effects of single doses could not be distinguished from those of the calculated numerically equivalent ret doses. In addition, there was not a significant difference demonstrated between the fractionated and split‐course schedules.