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Cirrhosis and hepatoma occurring at Boston city hospital (1917‐1968)
Author(s) -
Purtilo David T.,
Gottlieb Leonard S.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197308)32:2<458::aid-cncr2820320225>3.0.co;2-b
Subject(s) - cirrhosis , medicine , hemochromatosis , alcoholic liver disease , gastroenterology , hepatocellular carcinoma , fatty liver , chronic hepatic , disease
Cirrhosis and hepatoma at Boston City Hospital have progressively increased in frequency, especially cirrhosis associated with chronic alcoholism. Alcoholic cirrhosis or fatty nutritional cirrhosis (FNC) increased from 31% (1917‐1926) to 61% (1955‐1968) of all types of cirrhoses. One third of 98 subjects dying of hepatoma had FNC. The occurrence of hepatoma associated with postnecrotic cirrhosis increased twofold and threefold in subjects with hemochromatosis. Chronic alcoholism was considered the pathogenetic agent implicated in the production of FNC, hemochromatosis, and post‐necrotic cirrhosis in 56 of our 98 patients dying of hepatoma. An average of 8 years ensued from the onset of alcoholic cirrhosis to the appearance of hepatoma in 23 alcoholic patients.