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Sinus histiocytosis with massive lymphadenopathy. Report of a case associated with elevated EBV antibody titers
Author(s) -
Lober Marianne,
Rawlings William,
Newell Guy R.,
Reed Richard J.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197308)32:2<421::aid-cncr2820320220>3.0.co;2-d
Subject(s) - mononucleosis , medicine , sinus histiocytosis with massive lymphadenopathy , epstein–barr virus , titer , immunology , rubella , virus , histiocytosis , antibody , antibody titer , virology , pathology , measles , disease , vaccination
A case of sinus histiocytosis with massive lymphadenopathy is reported in which the patient had higher than expected antibody titers against the Epstein‐Barr (EBV) and rubella viruses. In addition, high anti‐EBV titers in family members physically separated suggest an altered immunologic reactivity which could be important in the development of the massive lymphadenopathy associated with this syndrome. The relationship of this syndrome to the EBV along with its histologic characteristics suggest that it may represent a peculiar, late sequelae of infection with this virus, or an atypical manifestations of infectious mononucleosis in an immunologically defective individual.