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Perineural invasion and anaplastic transformation of verrucous carcinoma
Author(s) -
Demian Saba D. E.,
Bushkin Frederic L.,
Echevarria Rene A.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197308)32:2<395::aid-cncr2820320217>3.0.co;2-e
Abstract Verrucous carcinoma is a unique variant of squamous cell cercinoma. Fifteen cases are presented. 11 were in the oral cavity, 3 in the larynx, and 1 in the uterine cervix. Anaplastic transformation of this lesion after radiation therapy, in about 30% of cases, is well documented in the literature but was not seen in our series. The reason for this change, which is usually within a matter of months, is not certain. In two entirely sectioned cases, no areas of synchronous poorly differentiated carcinoma were found. In our series, three of four primary lesions treated by radiation therapy recurred, while only 5 out of 11 cases of those treated surgically recurred. Surgical resection remains the treament of choice. Perineural invasion of verrucous carinoma appears to be rare. One such case is fully documented here. The patient is free of tumor after 6 years. Perineural invasion may represent invasion along the least resistant tissue planes by this biologically not so aggressive tumor. Further microscopic examination of verrucous carcinoma in all sites is necessary to attempt to correlate perineural invasion with prognosis.