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Radiation control of microscopic pulmonary met ast ases in C3H mice
Author(s) -
Shaeffer James,
ElMahdi Anas M.,
Constable William C.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197308)32:2<346::aid-cncr2820320210>3.0.co;2-0
Subject(s) - lung , medicine , adenocarcinoma , subclinical infection , pathology , in vivo , stage (stratigraphy) , irradiation , lung cancer , radiation therapy , nuclear medicine , cancer , radiology , biology , paleontology , physics , microbiology and biotechnology , nuclear physics
C3HBA adenocarcinoma cells injected intravenously into isogeneic C3H/HeJ mice result in the formation of visible lung colonies which are introduced as a model for pulmonary metastases. Visible lung colonies are both time dependent and injected cell number dependent. Control of the lung colonies at their microscopic (subclinical) stage is achieved by a single radiation dose of 2100 rads, which is far less than the dose necessary to control palpable primary tumors. An in vivo survival curve for the microscopic lung colonies irradiated with graded single doses is resented.