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Studies of mortality and health status in women cured of cancer of the cervix uteri. Comparison of long‐term results of radiotherapy and combined surgery and radiotherapy
Author(s) -
Kielbinska Stefania,
Tarlowska Ludwika,
Frajczek Olimpia
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197307)32:1<245::aid-cncr2820320136>3.0.co;2-u
Subject(s) - medicine , radiation therapy , cervix , incidence (geometry) , cancer , cervical cancer , mortality rate , hysterectomy , population , corpus uteri , surgery , survival rate , obstetrics , gynecology , physics , environmental health , optics
Long‐term follow‐up was undertaken of two groups of women who had been evaluated as cured of Stage I cancer of the cervix uteri. One group included 792 subjects treated by radiation alone; the other group included 789 women treated by irradiation after hysterectomy. No differences could be detected between these groups in general health status, mortality rate, cause of death, or the incidence of late recurrence of cancer. The only significant difference was in the type of long‐term complications. At the end of the period covered here, all patients had been followed for at least 7 years from the beginning of treatment. Follow‐up for a minimum of 10 years was achieved in 573 cases where radiotherapy alone was given and in 565 cases of combined therapy. Three hundred and one women from Group I and 206 from Group II were followed for a minimum of 15 years; 43 women from Group I and 34 from Group II were followed for a minimum of 20 years. The mortality rate in both groups during the 15 years following the first 5‐year survival period did not differ significantly from the mortality rate of the general population in the same age ranges. The most frequent cause of death was late recurrence of cancer, accounting for one third of the deaths in both groups. During the 15‐year observation period, the incidence of cancer recurrence decreased slowly with the duration of observation.