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Studies concerning the regional lymph node in cancer. VI. Correlation of lymphocyte transformation of regional node cells and some histopathologic discriminants
Author(s) -
Fisher Edwin R.,
Saffer Elizabeth,
Fisher Bernard
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197307)32:1<104::aid-cncr2820320114>3.0.co;2-b
Subject(s) - pathology , lymphocyte , lymph node , medicine , lymph , malignant transformation , carcinoma , nodal , cancer , lymphatic system , immunology
Regional nodes from patients with mammary carcinoma exhibited greater sinus histiocytosis and less lymph follicles than those from persons with colonic carcinoma. These latter tumors contained more lymphoid infiltrate, and their component cells had higher nuclear grades than breast carcinomas. Differences in the relationship of these histopathologic parameters with lymphocyte transformation of RLNCs in these two tumor types indicates the singularity of neoplasms of diverse origins. Lower nuclear grade and mild lymphoid infiltrate of mammary carcinoma were associated with nodal lymph follicle formation and the converse with the absence of such nodal structures. No significant differences in these histopathological discriminants were observed in patients with or without nodal metastases. Lymphocyte transformation of RLNCs from patients with mammary carcinoma was increased in those in whom their carcinomas were of low nuclear grade and contained only mild degrees of lymphoid infiltrate. These findings suggest that nuclear grade and lymphoid infiltrates may be differently related to tumor host responses than previously contended. No functional or other relationships could be discerned for sinus histiocytosis. Ultrastructurally, cells comprising this latter lesion appeared as banal macrophages. Activated lymphocytes appeared to represent the morphological analog of lymphocyte transformation.