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Oat cell carcinoma of the pancreas with ectopic ACTH secretion
Author(s) -
Corrin B.,
Gilby E. D.,
Jones N. F.,
Patrick J.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197306)31:6<1523::aid-cncr2820310633>3.0.co;2-8
Subject(s) - histogenesis , medicine , anaplastic carcinoma , oat cell carcinoma , metastasis , pancreas , carcinoma , endocrine system , secretion , pathology , islet , lung , cancer research , endocrinology , cancer , respiratory disease , hormone , insulin , immunohistochemistry
The clinical and biochemical findings in a case of ectopic ACTH secretion are reported in detail with particular reference to the disturbances in potassium and sodium metabolism. Biopsy of an hepatic metastasis during life showed oat cell carcinoma, but after death meticulous search of the lungs showed no tumor. Subsequent investigations suggested that the growth was an unusually anaplastic pancreatic islet cell tumor. The histogenesis of oat cell carcinomas is discussed and it is concluded that these tumors are not exclusively pulmonary in origin but all may be regarded as having an endocrine derivation.