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Preoperative irradiation for osteogenic sarcoma
Author(s) -
Allen Clifford V.,
Stevens Kenneth R.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197306)31:6<1364::aid-cncr2820310610>3.0.co;2-i
Subject(s) - medicine , sarcoma , biopsy , surgery , cancer , tourniquet , amputation , irradiation , radiology , pathology , physics , nuclear physics
High‐dose preoperative irradiation with delayed disarticulation of an extremity involved with osteogenic sarcoma has resulted in a marked increase of tumor‐free survival in a small series of cases treated at the University of Oregon Medical School. Treatment was well tolerated without significant complications. The surgical specimen in most of the survivors contained no viable carcinoma after irradiation in the order of 10,000 rads. There is evidence that biopsy in suspected lesions should be performed without tourniquet to avoid flushing of the tumor cells from the marrow cavity. Discussion will include rationale for delayed surgery, possible influence of irradiation on immune factors, and techniques of irradiation.