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Tryptophan metabolism in breast cancer. correlation with urinary steroid excretion
Author(s) -
Davis H. L.,
Brown R. R.,
Leklem J.,
Carlson I. H.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197305)31:5<1061::aid-cncr2820310504>3.0.co;2-w
Subject(s) - etiocholanolone , androsterone , excretion , endocrinology , kynurenine , medicine , breast cancer , tryptophan , urinary system , cancer , hormone , physiology , steroid , biology , amino acid , biochemistry
Urinary excretion of tryptophan metabolites, etiocholanolone, androsterone, and 17‐hydroxycorticosteroids (17‐OHc.s.), was measured in 25 patients with breast cancer and in 12 similarly aged control women. Twelve of the 25 patients had elevated excretions of metabolites of the kynurenine‐niacin pathway, and, in these patients, the excretion of etiocholanolone was significantly lower than in controls or in patients with normal tryptophan metabolism.