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Effect of excision or local radiotherapy to a tumor and its regional nodes on metastases
Author(s) -
McCredie John A.,
Inch W. Roger,
Cowie Harold C.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197304)31:4<983::aid-cncr2820310432>3.0.co;2-e
Subject(s) - medicine , fibrosarcoma , radiation therapy , mammary carcinoma , hindlimb , lung , methylcholanthrene , metastasis , immune system , pathology , carcinoma , cancer , surgery , carcinogen , immunology , biology , genetics
The incidence of lung metastases was determined following excision or local radiotherapy to the established immunologically weak syngeneic C3HBA mammary carcinoma or transplants of the syngeneic immunologically strong methylcholanthrene‐induced fibrosarcoma. The tumors were grown in the hind legs of C3H/HeJ mice. The regional nodes were included in the operative specimen and in the field of radiotherapy. It was found that lung metastases were the same in mice that had the tumor‐bearing leg amputated or irradiated. The treatments, therefore, did not act or had the same effect on the immune response of the host.