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Continuous intravenous infusions of 5‐fluoro‐2′‐deoxyuridine in the treatment of solid tumors
Author(s) -
Deconti Ronald C.,
Kaplan Stephen R.,
Papac Rose J.,
Calabresi Paul
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197304)31:4<894::aid-cncr2820310420>3.0.co;2-k
Subject(s) - medicine , leukopenia , toxicity , rash , stomatitis , gastroenterology , sepsis , diarrhea , carcinoma , surgery
Seventy patients with far advanced neoplastic disease were treated with 5‐fluoro‐2′‐deoxyuridine by continuous intravenous infusion at 1 mg/kg/day for periods of 2 to 16 days until evidence of toxicity became apparent. In all, 143 courses of therapy were administered. Toxicity consisted of leukopenia (58%), stomatitis (58%), diarrhea (36%), and skin rash (10%); these were generally mild and well tolerated though three patients died with sepsis during periods of severe leukopenia. The median duration of drug therapy until the onset of toxicity was 6 days and this did not appear to be influenced by gross involvement of liver by tumor. Seven of 16 patients with carcinoma of the breast responded to the drug, and in three of these, the duration of response exceeded one year. Six of 10 patients with gastric carcinoma and 3 of 34 patients with colon and rectal carcinoma achieved objective responses though these were of considerably shorter duration.