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Mithramycin in the treatment of metastatic ewing's sarcoma
Author(s) -
Kofman Sydney,
Perlia Charles P.,
Economou Steven G.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197304)31:4<889::aid-cncr2820310419>3.0.co;2-h
Subject(s) - medicine , sarcoma , cyclophosphamide , oncology , disease , clinical trial , chemotherapy , pathology
Five patients with progressive, metastatic Ewing's sarcoma were treated with infusions of mithramycin. Two had excellent regressions of their tumors; one patient has no clinical evidence of tumor more than 7 years after mithramycin was given. Patients who are resistant to cyclophosphamide may respond to mithramycin and vice versa. The exact role of mithramycin in patients with Ewing's sarcoma is not known. Further experimental trials are indicated with mithramycin alone and in combination both as adjunctive therapy and for the treatment of metastatic disease.