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Lack of identifiable vascular invasion in patients with extranodal dissemination of hodgkin's disease
Author(s) -
Lamoureux Kent B.,
Jaffe Elaine S.,
Berard Costan W.,
Johnson Ralph E.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197304)31:4<824::aid-cncr2820310409>3.0.co;2-2
Subject(s) - medicine , occult , disease , stage (stratigraphy) , pathology , histology , biopsy , paleontology , alternative medicine , biology
Abstract Retrospective review of a carefully studied Hodgkin's disease series identified 12 patients with limited (early stage) clinical involvement who developed extranodal dissemination of disease following primary treatment with irradiation. The original biopsy material was available for 11 of these cases and was reexamined for evidence of blood vessel invasion by tumor using appropriate histologic techniques including stains for elastic tissue. Vascular invasion could not be recognized in any sections examined for either these patients with relapse or for disease‐free patients from the same series matched for age, sex, clinical stage of disease, and histologic subclassification. Thus, while the identification of vascular invasion reportedly correlates with an increased risk of occult dissemination of Hodgkin's disease, this histologic determinant would not have served as an indicator of biological behavior in the series reviewed. Our experience suggests a more reliable index of high risk for extranodal dissemination is provided by clinicohistologic correlation, the greatest risk existing for patients having constitutional symptoms associated with mixed cellularity and lymphocyte‐depleted histology.