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Hodgkin's disease in children
Author(s) -
Schnitzer Bertram,
Nishiyama Ronald H.,
Heidelberger Kathleen P.,
Weaver Don K.
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197303)31:3<560::aid-cncr2820310310>3.0.co;2-f
Subject(s) - medicine , nodular sclerosis , stage (stratigraphy) , disease , biopsy , multiple sclerosis , pediatrics , pathology , lymphoma , hodgkin lymphoma , paleontology , psychiatry , biology
Relatively few studies of Hodgkin's disease (H.D.) in children have used the histologic criteria of the Rye classification. In our study, 55 cases of H.D. in children of 15 years and younger were histologically classified according to the Rye scheme. The cases were divided into 3 groups: 1. all patients, 2. those in their first decade of life, and 3. those aged 11 through 15. The majority of children were boys (62%). Nodular sclerosis was the most frequent histologic type seen in all children (49%) and in the third group (57%), whereas no preponderant histologic type was seen in the younger age group. Most cases of lymphocytic predominance were clinical Stage I, and the bulk of the long‐term survivors had this histologic type. Although seen in all clinical stages at the time of diagnostic biopsy, most cases of nodular sclerosis were Stage II. Prognosis of patients with nodular sclerosis was considerably worse than that of children with lymphocytic predominance. The results of our study are compared to those of other investigators.