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Proteinaceous precipitate in nodular (follicular) lymphomas
Author(s) -
RosasUribe Arturo,
Variakojis Daina,
Rappaport Henry
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197303)31:3<534::aid-cncr2820310307>3.0.co;2-n
Subject(s) - nodule (geology) , histiocyte , medicine , pathology , malignant lymphoma , lymphoma , follicular lymphoma , electron micrographs , electron microscope , biology , paleontology , physics , optics
A heretofore undescribed proteinaceous material was observed within the neoplastic nodules of malignant lymphomas with nodular patterns. The amount of this precipitate varied from case to case and from nodule to nodule. Malignant lymphoma, poorly differentiated lymphocytic type, was diagnosed in five patients, and malignant lymphoma, mixed cell type (lymphocytic‐histiocytic) was seen in the remaining eight cases. No correlation was found between the amount of the proteinaceous precipitate and the clinical behavior. Of 13 patients in this study, 9 were alive, with or without clinical evidence of lymphoma from 5 to 58 months after onset of symptoms. The remaining four patients died 12, 28, 42, and 48 months after clinical onset, with clinical evidence of disseminated disease at the time of their death. Eight patients were women and five were men. Their ages ranged from 34 to 76 years. Special histochemical procedures failed to reveal the nature of the precipitate, and electron micrographs prepared from one patient showed extracellular clusters of a fine fibrillar material of unknown nature.