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Therapy with carbenicillin and gentamicin for patients with cancer and severe infections caused by gram‐negative rods
Author(s) -
Klastersky Jean,
Cappel Roger,
Daneau Didier
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197302)31:2<331::aid-cncr2820310210>3.0.co;2-s
Subject(s) - carbenicillin , gentamicin , medicine , aminoglycoside , ototoxicity , antibiotics , gram , gastroenterology , microbiology and biotechnology , chemotherapy , bacteria , cisplatin , biology , genetics
Gentamicin, carbenicillin, and the combination of gentamicin and carbenicillin were used at random to treat severe bacteriologically proven infections caused by gram‐negative bacilli. In 68 patients with disseminated cancer, favorable results were observed in 13 out of 23 (57%), 11 out of 22 (50%), and 19 out of 23 (83%) of the patients, respectively. These results correlated well with the higher antibacterial activity found in sera of patients who received the combination of gentamicin and carbenicillin as compared to sera of patients treated with carbenicillin or gentamicin alone. Gentamicin was used in this series at doses ranging from 6 to 8.5 mg/kg/day without the development of serious ototoxicity, or renal toxicity.