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Significance of growth rates, cell kinetics, and histology in the irradiation and chemotherapy of squamous cell carcinoma of the mouth
Author(s) -
Friedman Milton,
Nervi Carlo,
Casale Carlo,
Starace Giuseppe,
Arcangeli Giorgio,
Page Giorgio,
Ziparo Elio
Publication year - 1973
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197301)31:1<10::aid-cncr2820310103>3.0.co;2-z
Subject(s) - histology , medicine , chemotherapy , basal cell , radiation therapy , oral cavity , cell , cancer , pathology , carcinoma , epidermoid carcinoma , oncology , biology , dentistry , genetics
In eight cases of extended tumors of oral cavity, we have studied the growth rate, the cell kinetics parameters, and the histology before and during treatment. We have found that growth rate and cell kinetics are not useful for clinical purposes because the first is not related to the response to treatment, while the second is unable to give relevant parameters in solid human tumors. New information was obtained from examination of serial biopsies before and throughout the treatment. These data suggest that multiple subpopulation groups of cancer cells with different intrinsic sensitivity to chemotherapy and/or radiotherapy may exist in the same tumor. Resistance of the tumor is related to some groups of cells scarcely sensitive to treatment.