Premium
Thorotrast‐induced hepatoma
Author(s) -
Smoron Geoffrey L.,
Battifora Hector A.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197211)30:5<1252::aid-cncr2820300517>3.0.co;2-w
Subject(s) - thorotrast , medicine , thorium dioxide , pathology , nuclear medicine , chemistry , nuclear chemistry
A case of thorotrast‐induced hepatoma is presented. The patient was given Thorotrast intravenously, in 1943, for diagnostic x‐ray studies. Autoradio‐graphic and electron microscopic studies confirm the diagnosis 28 years later. A review of the world's literature is tabulated. A short history of the use of thorotrast is given, and its carcinogenic potential is discussed. The question of chemical vs. radiation carcinogenesis remains unsettled. A plea is made for earlier diagnosis, so that an effective plan of treatment may be attempted.