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Epithelioid sarcoma. A light and electron microscopic study suggesting a synovial origin
Author(s) -
Gabbiani Giulio,
Fu YaoShi,
Kaye Gordon I.,
Lattes Raffaele,
Majno Guido
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197208)30:2<486::aid-cncr2820300229>3.0.co;2-f
Subject(s) - pathology , synovial sarcoma , epithelioid cell , ultrastructure , epithelioid sarcoma , cytoplasm , sarcoma , stromal cell , ground substance , stroma , histiocyte , electron microscope , medicine , biology , immunohistochemistry , microbiology and biotechnology , connective tissue , physics , optics
Two cases of “epithelioid sarcoma” were studied by light and electron microscopy. In both cases, the tumor consisted of a collagen‐rich fibrous stroma with nests of large epithelial‐like cells with acidophilic cytoplasm, giving the neoplastic tissue a biphasic pattern. The ultrastructural study showed that the tumor cells were of three types: “clear” and “dark” cells (recalling those of the synovium and synovial sarcoma) with distorted nuclei and abundant cytoplasm, and a less common, more immature cell. The histologic and ultrastructural features of the neoplastic cells, as well as those of the ground substance, indicate that the tumor is neither of chrondroid nor of histiocytic origin. The cells of the epithelioid islands are similar to the stromal component of synovial sarcoma. It is suggested that epithelioid sarcoma may be a variant of this tumor.