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Hexokinase isozyme patterns of human uterine tumors
Author(s) -
Kikuchi Yoshihiro,
Sato Shigeaki,
Sugimura Takashi
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197208)30:2<444::aid-cncr2820300222>3.0.co;2-9
Subject(s) - hexokinase , isozyme , uterine cervix , myometrium , medicine , in utero , carcinoma , uterus , pathology , endocrinology , biology , enzyme , biochemistry , glycolysis , pregnancy , metabolism , fetus , genetics
Hexokinase isozyme patterns of human uterine carcinomas and myomas were studied using cellulose acetate membrane electrophoresis. Uterine carcinomas of the cervix and corpus contained type II hexokinase as well as type I, unlike normal uterine cervical epithelium and endometrium which contained only type I. The hexokinase activities of carcinoma tissues were also higher than those of control tissues. Uterine myomas contained only type I hexokinase, like normal myometrium, and had similar specific activity to the latter. The abnormality in the pattern of hexokinase isozymes in human tumors and the application of this in clinical diagnosis of human cancers are discussed.