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Therapeutic evidence for and implications of cell age cohort variation during tumor growth
Author(s) -
Maruyama Yosh,
Lee T. C.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<84::aid-cncr2820300114>3.0.co;2-1
Subject(s) - rna , cell , cell cycle , cell growth , cell division , population , dna , mitosis , medicine , dna synthesis , biology , andrology , immunology , microbiology and biotechnology , genetics , environmental health , gene
Abstract DNA and RNA synthesis were studied during growth of the LSA ascites lymphoma. DNA and RNA per cell rose during lag phase, then fell with the beginning of cell division. During early and mid‐logarithmic growth phase, DNA and RNA per cell underwent increases and then fell with plateau phase. The macromolecular content of tumor cells returned to value comparable with normal spleen cells in the terminal mouse. H 3 ‐TdR uptake paralleled but preceded a rise in DNA/cell content but fell in the terminal mouse. The data indicate considerable variation in cell activity during growth. A large fraction of the population is in S during early and mid‐exponential growth, but this declined in late tumor growth. The tumor cells in the terminal mouse appeared to collect in G 1 as it ceased proliferative activity and entered a non‐proliferative state. Considerable variation of age cohorts' composition of tumor cells at different stages of tumor growth was evident. These data indicate that different therapies are appropriate to the different stages of tumor growth based upon the principal activities of the age cohorts present at that time.