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Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia
Author(s) -
Canellos George P.,
WhangPeng Jacqueline,
Schnipper Lowell,
Brown Clarence H.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<288::aid-cncr2820300140>3.0.co;2-a
Subject(s) - medicine , chronic granulocytic leukemia , prednisone , vincristine , spontaneous remission , karyotype , leukemia , chromosome , philadelphia chromosome , immunology , gastroenterology , chemotherapy , genetics , pathology , biology , chromosomal translocation , cyclophosphamide , alternative medicine , gene
A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.