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Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer
Author(s) -
Djerassi Isaac,
Rominger C. Jules,
Kim Jung Sun,
Turchi Joseph,
Suvansri Udom,
Hughes David
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<22::aid-cncr2820300105>3.0.co;2-b
Subject(s) - medicine , methotrexate , folic acid antagonists , lung cancer , folic acid , cancer , oncology
Abstract A Phase 1 study of high‐dose “pulse” methotrexate infusions combined with citrovorum factor “rescue” in advanced lung cancer indicated consistent tumor response in eight patients. A dose schedule allowing for repeated treatments, and thus suitable for prolonged management, was developed. Three patients treated accordingly for 8 to 10 months continue to show regression of their original lesions without evidence of new metastases. These observations are consistent with previously proposed concepts for use of citrovorum “rescue” after administration of high‐dose “pulses” of folic acid antagonists.