Premium
Multiple myeloma associated with a 9S IgG paraprotein and carcinoma of the prostate
Author(s) -
Chin ChangKon,
Smith Linda L.,
Wright ClaudeStarr,
Barton Betty P.,
Moores Russell R.,
Lutcher C. Lawrence
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<206::aid-cncr2820300130>3.0.co;2-p
Subject(s) - multiple myeloma , medicine , immunoglobulin light chain , myeloma protein , prostate , hyperviscosity , adenocarcinoma , globulin , prostate cancer , antibody , immunology , cancer , blood viscosity
A case of multiple myeloma associated with a 9S IgG complex. kappa‐type light chains, and adenocarcinoma of the prostate is described. The relative amount of 9S globulin was independent of total protein concentration; it was the predominant M‐component in both highly diluted serum and also in whole serum. At low p H, it was dissociated to the 7S monomer. The presence of moderately high concentrations of the 9S species in the patient's serum did not cause symptoms of the hyperviscosity syndrome. A review of the literature suggests that the association of myeloma with nonreticular neoplasms may occur more often than previously supposed.