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Regression of metastatic renal cell carcinoma following nephrectomy
Author(s) -
Garfield David H.,
Kennedy B. J.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<190::aid-cncr2820300127>3.0.co;2-h
Subject(s) - nephrectomy , medicine , renal cell carcinoma , disease , carcinoma , kidney , hormone , urology , surgery
Regression of pulmonary metastases following nephrectomy for renal cell carcinoma has occurred in two patients. In one patient, a hepatopathy also disappeared, and the patient remained free from disease for 16 years. In the other patient, following nephrectomy there was disappearance of hypercalcemia, presumably due to removal of a source of production of a parahormone‐like polypeptide. It appears that older males with only pulmonary metastases make up the majority of patients in whom regression of metastases after nephrectomy has been observed. Hormonal and immunologic factors are implicated in this phenomenon. There is a sound rationale for nephrectomy in the presence of metastatic renal cell carcinoma.