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Pathology of carcinoma of the lung associated with asbestos exposure
Author(s) -
Kannerstein M.,
Churg J.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<14::aid-cncr2820300104>3.0.co;2-9
Subject(s) - asbestos , medicine , carcinogen , carcinoma , pathology , lung , lung cancer , population , cigarette smoke , incidence (geometry) , cigarette smoking , physiology , oncology , biology , genetics , materials science , physics , environmental health , optics , metallurgy
Fifty cases of carcinoma of the lung in patients occupationally exposed to asbestos were compared with 50 matched control cases of carcinoma of the lung. The two series differed significantly only in the distribution of the tumors in relation to upper and lower lobes. Another statistically less striking difference was a somewhat more frequent severe pleural involvement in the exposed group. Position within a lobe, cell types, and metastatic incidence and pattern showed no significant difference between the two series. This essential similarity would appear to be in agreement with epidemiologic and experimental investigations indicating that asbestos is a co‐carcinogen. It is weak in itself, but markedly augments the effect of another potent carcinogen which in the human population is probably cigarette smoke.