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Anaplastic spindle‐cell and giant‐cell tumors of the thyroid gland
Author(s) -
Nishiyama Ronald H.,
Dunn Ernest L.,
Thompson Norman W.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197207)30:1<113::aid-cncr2820300118>3.0.co;2-e
Subject(s) - thyroid , medicine , pathology , anaplastic carcinoma , medullary cavity , follicular cell , cell , papillary carcinoma , clear cell , follicular phase , carcinoma , thyroid carcinoma , biology , genetics
Fifty‐three cases of anaplastic spindle‐cell and giant‐cell tumors of the thyroid gland were found in the files of the University of Michigan Medical Center in a 37‐year period (1932‐1969). Of these, 42 were found with other well‐differentiated thyroid carcinomas: papillary, follicular, Hürthle cell, clear cell, and medullary carcinomas. Data from this report and the recent literature support the conclusion that anaplastic tumors of the thyroid gland probably arise in preexisting well‐differentiated thyroid carcinomas. The grim prognosis for anaplastic carcinomas of the thyroid gland is reemphasized in this study; 49 of the 53 patients died within the first year after a histologic diagnosis was established.